Detail for Notch2


Full Name

Neurogenic locus notch homolog protein 2

Uniprot ID

Gene Name

NOTCH2

NCBI ID

Related Disease

  • Glioblastoma [ref.1]
  • Embryonal Brain Tumors [ref.2]
  • Breast Cancer [ref.3]

Therapy Method

Function

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation.

Related Pathway/CSCs feature

Reference

  • [1] NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts.
    Fan, X., et al. (2010). Stem Cells 28(1): 5-16.. [ 19904829 ]
  • [2] Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors.
    Fan, X., et al. (2006). Cancer Res 66(15): 7445-7452.. [ 16885340 ]
  • [3] Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells.
    Debeb, B. G., et al. (2012). Breast Cancer Res Treat 134(2): 495-510.. [ 22547109 ]

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