Detail for CD133


Full Name

Prominin-1

Uniprot ID

Gene Name

PROM1

NCBI ID

Related Disease

  • Colon Cancer [ref.1,2,3]
  • Breast Cancer [ref.1]
  • Non-small Cell Lung Cancer [ref.4]

Therapy Method

Function

May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner

Reference

  • [1] A novel mouse CD133 binding-peptide screened by phage display inhibits cancer cell motility in vitro.
    Sun, J., et al. (2012). Clin Exp Metastasis 29(3): 185-196.. [ 22228571 ]
  • [2] Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties.
    Bostad, M., et al. (2013). J Control Release 168(3): 317-326.. [ 23567040 ]
  • [3] Anti-human CD133 monoclonal antibody that could inhibit the proliferation of colorectal cancer cells.
    Chen, W., et al. (2010). Hybridoma (Larchmt) 29(4): 305-310.. [ 20715988 ]
  • [4] [1] Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells.
    PLoS One.2018 Jun 21;13(6):e0199361.. [ 29928062 ]

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