Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.
This enzyme catalyzes the first and rate-limiting step in the major pathway of L-tryptophan catabolism in mammals. This metabolic pathway is involved not only in a variety of physiological functions but also in many diseases, with special emphasis on the important role in evasion of T-cell-mediated immune rejection
 Antiproliferative activity of trans-avicennol from Zanthoxylum chiloperone var. angustifolium against human cancer stem cells.
Cebrian-Torrejon, G., et al. (2012). J Nat Prod 75(2): 257-261.. [ 22304006 ]