Detail for Farnesyl Transferase


Full Name

Protein farnesyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta

Uniprot ID

Gene Name

FNTA, FNTB

NCBI ID

Related Disease

  • Chronic Myeloid Leukaemia [ref.1, 2]

Function

FNTA: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
 
FNTB: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.

Related Pathway/CSCs feature

Reference

  • [1] The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells.
    Pellicano, F., et al. (2011). Leukemia 25(7): 1159-1167.. [ 21483442 ]
  • [2] BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors.
    Copland, M., et al. (2008). Blood 111(5): 2843-2853.. [ 18156496 ]

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