Detail for ALDH1


Full Name

Retinal dehydrogenase 1

Uniprot ID

Gene Name

ALDH1A1

NCBI ID

Related Disease

  • Breast Cancer [ref.1]
  • Malignant Pleural Mesothelioma(MPM) [ref.2]
  • Glioblastoma [ref.3]
  • Prostate Cancer [ref.3]
  • Pancreatic Cancer [ref.4]
  • Ovarian Cancer [ref.5]
  • Non-Small Cell Lung Cancer [ref.6]

Therapy Method

Function

Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid By similarity.

Related Pathway/CSCs feature

Reference

  • [1] High aldehyde dehydrogenase activity enhances stem cell features in breast cancer cells by activating hypoxia-inducible factor-2alpha.
    Kim, R. J., et al. (2013). Cancer Lett 333(1): 18-31.. [ 23174107 ]
  • [2] Cisplatin-resistant cells in malignant pleural mesothelioma cell lines show ALDH(high)CD44(+) phenotype and sphere-forming capacity.
    Cortes-Dericks, L., et al. (2014). BMC Cancer 14: 304.. [ 24884875 ]
  • [3] Suppressing glioblastoma stem cell function by aldehyde dehydrogenase inhibition with chloramphenicol or disulfiram as a new treatment adjunct: an hypothesis.
    Kast, R. E. and C. Belda-Iniesta (2009). Curr Stem Cell Res Ther 4(4): 314-317.. [ 19500061 ]
  • [4] Aldehyde dehydrogenase 1A1 confers intrinsic and acquired resistance to gemcitabine in human pancreatic adenocarcinoma MIA PaCa-2 cells.
    Duong, H. Q., et al. (2012). Int J Oncol 41(3): 855-861.. [ 22710732 ]
  • [5] beta-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.
    Condello, S., et al. (2014). Oncogene.. [ 24954508 ]
  • [6] Inhibitory effect of Disulfiram/copper complex on non-small cell lung cancer cells.
    Duan, L., et al. (2014). Biochem Biophys Res Commun 446(4): 1010-1016.. [ 24657266 ]

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