Detail for AMPKβ1


Full Name

AMPK subunit beta-1

Uniprot ID

Gene Name

PRKAB1

NCBI ID

Related Disease

  • Breast Cancer [ref.1, 2]
  • Pancreatic Cancer [ref.3]

Therapy Method

Function

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Related Pathway/CSCs feature

Reference

  • [1] Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells.
    Song, C. W., et al. (2012). Sci Rep 2: 362.. [ 22500211 ]
  • [2] Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells.
    Dowling, R. J., et al. (2007). Cancer Res 67(22): 10804-10812.. [ 18006825 ]
  • [3] Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells.
    Bao, B., et al. (2012). Cancer Prev Res (Phila) 5(3): 355-364.. [ 22086681 ]

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