Detail for CXCR1


Full Name

C-X-C chemokine receptor type 1

Uniprot ID

Gene Name

CXCR1

NCBI ID

Related Disease

  • Breast Cancer [ref.1]

Therapy Method

Function

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Reference

  • [1] CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts.
    Ginestier C, Liu S, Diebel M E, et al. J Clin Invest 120(2): 485-497.. [ 20051626 ]

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